American Society for Clinical Pharmacology and Therapeutics (ASCPT)

Director/Senior Director - Clinical Pharmacology

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Kartos Therapeutics
United States (remote)
4 days ago


Kartos Therapeutics is a privately held, clinical-stage biopharmaceutical company developing a potentially best-in-class MDM2 inhibitor. Launched in 2018 by proven industry veterans, we are a passionate team based in Redwood City, California and Bellevue, Washington. We have brought together scientists and clinicians with a deep understanding of hematology and oncology and an experienced leadership team. Together, we’re building an exciting biotechnology company with a culture defined by caring, ambition, dedication and teamwork!

Job Summary:

The Director/Sr Director of Clinical Pharmacology will be responsible for Kartos clinical pharmacology studies, population PKPD modeling and simulation (M&S), exposure-response analysis and regulatory interactions. In this role, the candidate will work closely with Kartos and CRO colleagues to ensure appropriate strategy and execution of clinical pharmacology studies and model-informed drug development (MIDD).


Clinical pharmacology, pharmacokinetics and pharmacometrics SME who applies clinical pharmacology regulatory strategy and M&S approaches to influence study design and decision making.

  • Scientific and strategic input into pre-clinical and clinical development plans
  • Operational leadership of Kartos clinical pharmacology studies
  • Help design and supervise modeling work performed by external contractors
  • Interpretation and reporting of M&S results
  • Contribute to regulatory documents and interactions
  • Support DMPK and bioanalytical aspects of both clinical and nonclinical studies as needed
  • Work in compliance with Good Clinical Practice (GCP) regulations



PhD, PharmD, or equivalent in clinical pharmacology, pharmacokinetics, or pharmacometrics

  • > ~10 years pharmaceutical industry experience in drug discovery and development
  • Supervisory level experience with clinical PK/PD and pharmacometrics analyses and modeling using software such as WinNonlin, R, NONMEM, and SIMCYP
  • PK/pharmacometrics lead in oncology and clinical pharmacology studies, with heme malignancy experience preferred
  • Excellent oral and written communication skills

Job Information

  • Job ID: 68490406
  • Workplace Type: Remote
  • Location:
    United States
  • Company Name For Job: Kartos Therapeutics
  • Position Title: Director/Senior Director - Clinical Pharmacology
  • Job Function: Research and Development
  • Setting: Biotechnology Company
  • Job Type: Full-Time
  • Job Duration: Indefinite
  • Min Education: PharmD
  • Min Experience: Over 10 Years
  • Required Travel: 0-10%
  • Salary: $245,000.00 - $265,000.00 (Yearly Salary)
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